Ap Biology Notes Cellular Communication Essay

Cell-to- mobile phone communication is essential in multi cubicleular organisms. They essential communicate to coordinate activities such as growth and development, and reproduction. In addition uni carrellular organisms communicate with each(prenominal) other. suggests may use light, or touch but we will focus on chemical foretells.1. outdoor(a) signals be converted to responses within the carrell a. Evolution of cell signal i. In yeast a cells and cells both secrete chemicals, which fuel but be received by the alternate type yeast. This signals the both cells to join via fusion 1. The process by which the signal on the surface of the cell is converted to a series of steps by the cell in response is called a signal transduction road ii. Signal transduction pathways are very similar in yeast and in complex multicellular organisms 2. This leads scientists to believe that this pathway evolved first in ancient prokaryotes b. Local and long distance foretoken iii. Local sig naling3. abutting cells of plants and animals may communicate through cell junctions a. Signaling substances dissolved in the cytoplasm travel amid cells i. Plants = plasmodesmataii. Animals = gap junctions4. Animal cells may use the followingb. Cell-to-cell recognitioniii. Direct contact between membrane- brim cell-surface shreds iv. serious in embryonic development and immune responsec. Paracrine signalingv. Uses local regulators which are goingd and travel only a short distance to nearby cells vi. Ex. Growth occurrenceors target nearby cells to grow and divide d. synaptic signalingvii. Electrical signal along a nerve cell triggers a chemical release across a synapse to trigger response in target cell viii.Ex. Nerve cellsiv. Long- distance signaling5. Both plants and animals use hormonese. Animals (endocrine signaling) cells release hormones which travel in the circulatory system to target cells f. Plants hormones travel in vessels or by diffusion through the air as gas g. H ormones vary in sizing and organize6. Nervous system signals can also be long distance c. The three stages of cell signaling A previewv. Reception when the target cell detects a signaling hint. The signaling element binds to a receptor protein on the target cells surface vi. Transduction After binding the receptor protein is substituted in some way, this converts the signal to a form that will bring about a proper(postnominal) cellular response7. May occur in a single step or a series of changes vii. Response The transduced signal triggers a particular proposition cellular response. 8. Catalysis of an enzyme, rearrangement of the cytoskeleton, activation of a particularised gene 2. Reception A signaling particle binds to a receptor protein, causing it to change shape d. To ensure signals are sent to the correct cell signaling molecules act as a ligand. viii. Ligand- molecule that specifically binds to another (usually larger) molecule ix. The receptor protein then usually changes shape x. May be determined on the membrane or inside the cell e. Receptors in the plasma membranexi. Water- fat-soluble signaling molecule binds to receptor on the membrane causing it to change shape or aggregate. f. Intracellular Receptors xii. represent in cytoplasm or nucleus of target cells9. Signaling molecule must be aquaphobic enough or small enough to pass through the plasma membrane h. Steroid hormones, thyroid hormones, nitric oxide Examples Pathway OtherG-Protein Coupled Receptors Yeast mating factors, epinephrine, hormones, neurotransmitters 1. signaling molecule binds to the g-protein receptor 2. receptor changes shape and the cytoplasmic side binds to the inactive G protein 3. GTP then displaces to form GDP and activates the protein 4. Activated G protein diffuses along the membrane to an enzyme altering the enzyme to trigger the next step Bacteria such as whooping cough, botulism and cholera disrupt this pathway Receptor Tyrosine Kinases Enzymes that cata lyze the transfer of phosphate groups 1. binding of dickens signaling molecules to two tyrosine chains causes the two to associate with each other forming a dimer2. dimerization activates the tyrosine kinase region to add a phosphate from and ATP to each tyrosine in the polypeptide 3. each tail can now bind to and activate a different specific relay protein within the cell One receptor may activate cardinal+ pathways. Absence can result in cancer Ion Channel Receptors Nervous system 1. signaling molecule binds to the ion persuade in the membrane 2. protein changes shape creating a channel through the membrane 3. specific ions can now flow through the membrane which may cause a change in the cell or trigger another pathway Some ion gated channels are controlled by change in voltage rather than binding of a ligandg. Intracellular Receptorsxiii. Ex. Testosterone10. Hormone passes through the plasma membrane 11. Testosterone binds to a receptor protein in the cytoplasm activating it 12. The hormone-receptor complex enters the nucleus and binds to a specific gene 13. The bound protein acts as a transcription factor, stimulating the transcription of the gene into mRNA 14. The mRNA is translated into a specific protein 3. Transduction cascades of molecular interactions relay signals from receptor to target molecules in the cell h. Protein phosphorylation and dephosphorylationxiv. Proteins can be trip by the addition of a phosphate group (often broken send off of ATP or GTP) 15. Phosphates are transferred from ATP to a protein by a general group of enzymes known as protein kinases i. Phosphorylation often causes the protein to change shape j. This happens because the added phosphate group interacts with polar or charged amino acids within the protein xv. Protein phosphatases are enzymes that back away phosphate groups from a protein 16. Mechanism for turning off signal transduction 17. These also allow for turning off and reusing pathways i. Small molecules and ions as second messengersxvi. Molecules other than proteins act as second messengers 18. Small and water soluble such as ionsk. This allows them to rapidly spread throughout the cell via diffusion 19. Second messenger refers to anything after(prenominal) the first messenger which is the extracellular signaling molecule that binds to the membrane 20. Most common second messengers are cyclic AMP and Ca+2 xvii. Cyclic AMP as a second messenger in response to the hormone epinephrine 21. Epinephrine binds to receptor molecule protein activates adenylyl cyclase which can catalyze the subtraction of many molecules of cAMP l. Adenylyl cyclase catalyzes the conversion of ATP into cAMP ix. cAMP usually activates a serine/threonine kinase known as protein kinase A which phosphorylates many other proteins m. cAMP is converted back to AMP by phosphodiesterase xviii. Calcium ions and inositol tripohosphate22. change magnitude calcium concentration causes responses such as muscle contraction, secretion of substances, and cell division in animals, and green in response to light in plants 23. Calcium is usually in high concentrations outside of the cell and in the ER but in low concentrations in the cytosol 24. Pathwayn. Signaling molecule binds to receptor o. Phospholipid pinches off membrane IP3 is released as second messenger p. IP3 binds to receptor on ER causing protein channel to open q. Ca+2 is released into cytosol4. Response Cell signaling leads to regulation of transcription or cytoplasmic activities j. Nuclear and cytoplasmic responsesxix. Pathways lead to the regulation of one or more cellular activities25. Regulate protein synthesisr. Turning specific genes on or off (calls for the synthesis of mRNA from DNA)26. Regulate protein activitys. pay back a shape change to turn a protein on or off27. Regulate overall shape change of cell28. Release of mating factors29. Cell divisionk. Fine-tuning of the responsexx. Signal elaboration30. Enzyme cascades amplify e ffects by increasing the product at each step t. Enzymes bear on active long enough to work on multiple products before becoming inactive xxi. The specificity of cell signaling and coordination of the response 31. Different types of cells are programmed to answer to only certain types of signals u. Some cells will respond to the same signals but in different ways v. This is because different cells have different collections of proteins xxii. Signaling energy scaffolding proteins and signaling complexes32. Scaffolding proteins increase the efficiency of the response w. A large protein with multiple protein kinases devoted x. Decreases the time of the response because diffusion between proteins is not needed 33. Pathways are not linear, in fact the same protein may act in multiple pathways 34. Relay proteins serve as branch points where the signal may go in one of two directions xxiii. Termination of the signal35. Each step in the pathway lasts only a short time, this makes the pr oteins ready for a new signal 36. When the signaling molecule leaves leave the receptor it reverts to its inactive form and the relay molecules follow